AcuSiS® (Accurate S<σ☆ip in Second）is a dr♦∏inking straw-like device designed t€≈≈¥o facilitate oral in±€↕gestion of pharmaceutical απ→granules or pellets for pediatric an♥±₩¶d geriatric patients who have di<π$fficulty in swallowing la>§₩∑rge size tablets and cap≥¥sules. The "Fill and Finish&quβ∏♦ot; device with a characteristic fea™₹ture of dynamic mixing allows patien<§✔ts to ingest the pharmaceutical ∏÷granules or pellets in a blinking↕ of an eye, thereby greatly ≥♠improving administration of medicineγ©≠ products to patients,✔↕∑↔ especially to the pres•§ ✘chool children who usua™ ↕lly experience medication phobia♠✔>™.
Figure 3 is the configuratio↕<n of the device.
Figure 3. AcuSiS® Configuration
Figure 4 demonstrates how AcuSiS¥$® enables easy and conven >ient dosing to patients. Due to iβ≤♣ts camouflage feature, AcuSiS↔₽® can be considered as a sugar-coa✔♦ting delivery platform"↑♦ to solve medication pho♥¶±bia usually experienced by pπ←πediatrics patients when us♣≠∞'ing other dosage forms, includi≥¶ng solution, suspension and✔& ODT et al.
Figure 4. AcuSiS®: Stealth Delivε₽§ery Device to solve medication pho←bia experienced by pediatrics with othe↕ r dosage forms
Similar to a dosing cup or a λ÷₹≥spoon for dosing of suspension, Acu€★←×SiS® is also designed to ← ≥deliver the granules to the patients. Tπλβhe granules in AcuSiS® ">;will be dispersed in-situ during☆₩$ sipping with water. As agreed upon bα↕y US FDA, AcuSiS® can s'✔♠erve as a container closure ∞βsystem. Hence Type IIIε©β↔ Packaging Material DMFs haveδ been submitted for AcuSiS€©®.
AcuSiS® has the following a∏®dvantages:
l Overcomes swallowing d≠♠ifficulties for the elderly and chil✘★dren;
l Easy to use, especially for patients wiφ↔↑₩th medication phobia;
l Rapid absorption and onset of action;
l Lower variability of drug dissolutiπ"♦on and absorption when combined wi£εφth an optimized granule formulation;
l Immediate use without the need÷₽₽ for preparation and special sto§™rage, reducing the burden oφ↑ n patients or carers≥♦™<;
l Using existing granules ↑"βεor pellets and a “Fill a✔×Ωnd Finish” process, easy implementation of the pe≤¥↓diatric study plan required by regulatory autho§↑≤rities;
l Very cost effective, fast track to co£≤£±mmercialization with greaλ∏t potential to extend product patent protection.
